Caffeine lowers fat and acts like a PCSK9 inhibitor!?Journal of Nature

2022-05-19 0 By

Current evidence suggests that coffee consumption may protect against cardiovascular disease.But the mechanism by which caffeine works has not been clear.Caffeine may play a cardiovascular protective role by lowering cholesterol, suggests a Canadian study published February 9 in Nature Communications.Researchers found that caffeine and its derivatives can cause a cascade effect, first of all to block a protein called SREBP2 activated (this can increase the liver PCSK9 protein expression, and transfer it to) in the blood, thus reducing PCSK9 levels in the blood, reduce its combination with liver surface LDL receptors, LDL in the blood – C was quickly cleared,And ultimately lower LDL-C.This molecular domino effect is similar to a rare genetic variation in the PCSK9 gene, which also reduces the production of PCSK9 in the liver, thereby lowering LDL-C levels.The study has broad implications because it links caffeine, a popular bioactive ingredient, to cholesterol metabolism at the molecular level, the researchers note.Given that SREBP2 is associated with a variety of cardiometabolic diseases, such as diabetes and fatty liver disease, the results could have further implications.The team has developed a new caffeine derivative that reduces BLOOD PCSK9 levels more strongly than caffeine, opening the way for new drugs to reduce LDL-C.Source:Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. Nature Many difficult and complicated cases, a doctor can only see once in his life:, please contact: 18656052587(wechat account) or zgxhzz@vip.163.com statement:This article is reproduced for the purpose of conveying more information.If the source is wrong or violated your legitimate rights and interests, please contact the author with proof of ownership, we will promptly correct, delete, thank you.Email address: newmedia@xxcb.cn